Interactions of natural deep eutectic solvents (NADES) with artificial and natural membranes

Natural deep eutectic solvents (NADES) are a third type of liquids, apart from water and lipids. NADES show promise as drug carriers in dermal formulations or for local administration the oral cavity due to their low toxicity, tunability biodegradability well solubilizing stabilizing properties. However, thorough investigation effects biological system is needed. The present study aimed investigate physicochemical properties six selected dilutions thereof. Further, suitability vehicles topical preparations was evaluated through application liposome model membranes ex vivo pig skin models. on membrane stability egg-phosphatidylcholine (Egg-PC) liposomes 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 16:0 PC (DPPC) were investigated by physical studies, permeability calorimetric analysis visual representation transmission electron microscopy (TEM). appeared most cases physically stable 24 h NADES, although there changes size morphology likely related increased osmolality. Some also able disaggregate formed DPPC aggregates. permeation studies indicated slightly reduced chloramphenicol after application, which caused hydrogen bonding between proteins based FT-IR-results. Altogether, our findings suggest that promising new delivery systems applications.